No association between OGG1 Ser326Cys polymorphism and breast cancer risk.

Introduction Breast cancer is the most common cancer among western women. Except for inherited mutations in the BRCA1, BRCA2, ATM, and p53 genes, little is known about the genetic risk factors for breast cancer. Recently, polymorphisms in genes involved in repair of DNA double-strand breaks were associated with risk of breast cancer (1). It has been proposed that oxidative stress contributes to breast cancer carcinogenesis (2). OGG1 encodes 8-oxo-guanine glycosylase, a key enzyme in repair of 8-oxo-guanine and other oxidative DNA damages. To investigate the possibility of an association between the polymorphism OGG1 Ser326Cys and breast cancer risk in postmenopausal women, we studied 425 cases and 434 controls, all recruited from the Danish Diet, Cancer and Health cohort.